ea0032p738 | Obesity | ECE2013
Maneschi Elena
, Vignozzi Linda
, Morelli Annamaria
, Mello Tommaso
, Filippi Sandra
, Cellai Ilaria
, Comeglio Paolo
, Sarchielli Erica
, Calcagno Alessandra
, Vettor Roberto
, Vannelli Gabriella Barbara
, Adorini Luciano
, Maggi Mario
Liver and visceral ectopic fatty tissue disposition is a major metabolic derangement leading to type 2 diabetes, hypertension, dyslipidaemia, recapitulated in the metabolic syndrome (MetS). We have demonstrated that the selective FXR agonist obeticholic acid (OCA, INT-747) ameliorates the metabolic profile and reduces visceral adipose tissue (VAT) in a high-fat diet (HFD)-induced rabbit model of MetS. We now report the effects of OCA treatment in HFD (0.5% cholesterol and 4% p...